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Approach to Identifying Disease-Modifying Genes
Human Studies
Human Tissues
Integrated genomic and proteomic
analysis of vein graft failure
Differentially expressed genes in failed coronary saphenous vein grafts: upregulated
Differentially expressed genes in failed coronary saphenous vein grafts: downregulated
Differentially expressed proteins in failed SVGs
Tissue extract – protein separation (ion exchange chromatography/gel-based)
Protease treatment
Tandem MALDI-TOF mass spectrometry (MS/MS) identification
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