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News, Events & Links
News | Siminars & Events | Links
News:
Inflammatory System Genes Linked to Cognitive Decline after Heart Surgery
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DURHAM, N.C. –Variants of two
genes involved in the inflammatory
system appear to protect patients
from suffering a decline in mental
function following heart surgery.
Duke University Medical Center
researchers believe their findings
could help physicians identify patients
at risk of suffering mental
decline after heart surgery and
raises the possibility that these patients
could be treated with drugs
that are known to dampen the inflammatory
response.
Six years ago, the Duke researchers demonstrated that 42 percent
of patients who underwent coronary artery bypass surgery
had measurable cognitive decline five years after their procedure.
Since that finding, the team has been investigating possible
reasons for this decline. MORE 
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Duke Researchers Uncover Genetic Link to Kidney Damage After Heart Surgery
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DURHAM, N.C. – Specific variants of genes involved in
inflammation and blood vessel constriction are strongly
associated with kidney damage in patients undergoing major
heart surgery, researchers at Duke University Medical Center
have found.
While renal dysfunction after heart surgery is a common occurrence, until now researchers have been unable to predict with any certainty which patients – based on their personal and medical characteristics – are at the highest risk. The current analysis showed that patients with the particular genetic variants, or polymorphisms, have a collective two- to four-fold greater likelihood of suffering renal dysfunction after heart surgery. MORE
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Duke Researchers Uncover Genetic Link to Stroke after Heart Surgery
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DURHAM, N.C. – Duke University Medical Center researchers have discovered that patients who have two specific gene variants are more than three times as likely to suffer a stroke after heart surgery.
Furthermore, since the two implicated genes are involved in the body’s immune response to insult or injury, the researchers said that their findings strongly suggest that inflammation plays an important role in postoperative stroke. MORE
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Gene Variants Predict Bleeding after Heart Surgery
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DURHAM, N.C. – Duke University Medical Center researchers have found that the presence of specific variants of genes that control clotting and the contractility, or "tone," of blood vessels can double the ability of physicians to predict those heart surgery patients at greatest risk of bleeding after surgery.
The issue of postoperative bleeding is important, the researchers said, because patients who suffer such episodes have increased rates of additional medical problems and even death. Furthermore, decreasing the rate of postoperative bleeding can have important implications for the health care system, they continued, since an estimated 20 percent of the nation’s blood supply is used to treat these patients. MORE
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Gene Variants Predict Heart Muscle Damage after Cardiac Surgery
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DURHAM, N.C. – Duke University Medical Center researchers have found that patients with six specific variants of genes involved in the body's immune response are significantly more likely to suffer damage of heart tissue after cardiac surgery.
These findings are important because current analytical methods cannot reliably predict who will be likely to suffer from myocardial infarction (MI), or heart tissue death after cardiac surgery. It is estimated that between 7 and 15 percent of patients undergoing coronary bypass surgery will suffer from a subsequent MI, the researchers said. MORE |
Seminars and Events:
Perioperative Genomics Meetings
All meetings are held at 4pm in Duke North Room 3452
| 2006 |
2007 |
December 21, 2005
"Duke involvement in the ATACAS trial: should we or shouldn’t we?"
Dr. Andrew Shaw |
January 3rd, 2007
"Cellular Models of Cardiovascular Injury"
Dr. Greg Michelotti |
January 4, 2006
"Update on Potential Commercial Applications and Strategies for Making the Infrastructure Financially Viable"
Dr. Debra Schwinn |
January 24th, 2007
"Genetic predictors of perioperative QTc prolongation"
Dr. Mihai Podgoreanu |
January 18, 2006
"Inflammation and bleeding – an update"
Dr. Ian Welsby |
February 28th, 2007
"Association of Sex-Linked MAO-A Polymorphism and Depression After CABG: Feasibility and Design of a Follow-up Study"
Drs. Barbara Phillips-Bute and Richard Morris |
February 8, 2006
"Circulating progenitor cells and cardiac surgery"
Dr. Madhav Swaminathan |
March 14th, 2007
Discussion with Dr. Winston Parris on the genomics of chronic pain. |
February 22, 2006
"Transformation of medicine and therapy by the genome program"
IGSP Distinguished Lecturer
C. Thomas Caskey, MD |
March 21st, 2007
"Functional genomic approaches to perioperative endothelial injury and dysfunction"
Drs. Sol Aronson & Tony Roche |
March 8, 2006
"Risk stratification for long-term cardiac surgical outcomes: Implications for design of genetic association studies"
Dr. Mihai Podgoreanu |
June 13th, 2007
"Genome Profiling for Genetic Risk Stratification"
Dr. Richard Morris |
March 15, 2006
Perioperative Genomics Team Building Session |
June 27th, 2007
"Genomic Predictors of Long-Term Mortality following CABG Surgery"
Dr. Robert Lobato |
March 22, 2006
"Identifying population substructure in a genome wide association study"
Dr. Richard Morris |
July 25th, 2007
"Duke Division of Clinical Informatics: Overview of Research Activities and Potential Opportunities for Collaboration"
Kensaku Kawamoto, Ph.D. |
April 5, 2006
Perioperative Genomics Team Building Session II
Dr. Andrew Shaw |
October 24, 2007
"Whole Genome Association Study Design & Cohort Selection"
Group discussion |
April 12, 2006
Thoracic R21 Grand and Summary statement
Dr. Andrew Shaw |
November 14, 2007
"Post-Cardiac Surgery Acute Injury - Functional Effects of Apolipoprotein E Phenotypes, & the Complex Relationship between Genotypes & Ethnicity"
Dr. Mark Stafford-Smith |
April 26, 2006
"Ranks of genuine associations in a whole genome association study"
Dr. Richard Morris |
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May 10, 2006
"Improving Duke’s perioperative genomics research infrastructure: task descriptions"
Dr. Mihai Podgoreanu |
|
May 17, 2006
Improving Duke’s perioperative genomics research infrastructure
Dr. Andrew Shaw |
|
May 31, 2006
"Genomic modifiers of perioperative atrial fibrillation"
Dr. Mihai Podgoreanu |
|
June 7, 2006
"Modeling post bypass acute renal failure in the rat"
Dr. Chris Sulzer |
|
June 14, 2006
"Detecting genetic association in the presence of genetic heterogeneity"
Dr. Richard Morris |
|
June 28, 2006
"Urinary biomarker discovery in acute renal failure"
Dr. Andrew Shaw |
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October 11th, 2006
"Preliminary overview of lung resection – genotype data"
Dr. Richard Morris |
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November 15th, 2006
"Whole genome analysis of postoperative cognitive decline – preliminary results"
Dr. Mihai Podgoreanu |
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December 6th, 2006
"Discussion of Kidney Analysis in Pilot WGA Data"
Group Discussion |
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Genomes @ 4
Genomes@4 consists of bi-weekly presentations engaging diverse perspectives on the impact of the Genome Revolution. All presentations are held from 4-5pm in the Schiciano Auditorium (Side B), Fitzpatrick-CIEMAS Building and are followed by an IGSP Social Hour in the 2nd floor lobby.
December 7th, 2006 [More Information]
"A Genomic Approach to Personalized Medicine in Lung Cancer"
Anil Potti
January 18th, 2007
“Genome Science-Based Enhancements of Human Beings: Some Ethical Issues”
Allen Buchanan
http://calendar.duke.edu/calendar.nsf/EventID/6X4SYJ
February 1st, 2007
“The Nonribosomal Code: Products from the Biosphere's Microbial Drug Factories”
Bruce Donald
http://calendar.duke.edu/calendar.nsf/EventID/6X4T26
February 15th, 2007
“Signatures for Drug Discovery”
Todd Golub
http://calendar.duke.edu/calendar.nsf/EventID/6X4T3B
March 15th, 2007
"Offensive Science: The Case of HIV/AIDS"
Sherryl Broverman - Dept. of Biology
http://calendar.duke.edu/calendar.nsf/EventID/6XAKH6
April 5th, 2007
"Studying Gene-Environment Interactions in Human Diseases"
Marcy Speer and Silke Schmidt
http://calendar.duke.edu/calendar.nsf/EventID/6XJS9R
April 19th, 2007
"Stem Cells: Advances in Research and Issues for Clinical Practice"
Tannishtha Reya and Philip Rosoff
http://calendar.duke.edu/calendar.nsf/EventID/6XJS7U
Genomic Medicine Forum
Thursday's | 9:00 am – 10:30 am | CIEMAS Room 2240
www.genome.duke.edu/genomicmedicineforum
November 8, 2007
"Clinomics"
A. Jamie Cuticchia, Jr., PhD
November 29, 2007
"Integrating Clinical, Pathologic & Genomic Profiles to Individualized Cancer Therapy"
Anil Potti, MD
December 6, 2007
"Metabolomics in Cardiovascular Disease"
Svati Shah, MD
December 13, 2007
The Use of Gene Expression as a Biological Phenotype to Explore and Anticipate CancerBehavior
Phillip G. Febbo, MD
December 20, 2007
Communication Genomics For The Research/Patient Communites
Julianne O'Daniel, MS, CGC &
N. Christin Oien, MS, CGC
January 3, 2008
Alzheimer's Disease: What is Upstream From the "Amyloid Cascade": Whole Genome Insights into New Targets for Therapy
Allen Roses, MD
Gene-MAGIC meetings:
Check back for updates.
Links:
http://cardiology.duke.edu/modules/div_cv_rsch_cggs/index.php?id=1
http://people.genome.duke.edu/~merri034/CVGenomics/
http://www.askbig.org/
http://www.dcri.duke.edu/
http://www.genome.duke.edu/
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