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PEGASUS Research Projects
Cognitive Decline
- The PEGASUS team looked at 513 patients undergoing cardiac surgery with CPB
- At 6-weeks postoperatively, incidence of postoperative cognitive decline was found in 35.7% (183/513) of the patients.
- Analysis was adjusted for age, level of education, baseline cognition and population substructure
- 37 candidate SNPs examined
Mathew JP et al., JACC 2006 submitted
A Genetic Basis for Cognitive Decline After Cardiac Surgery
- It was found that 2 minor alleles protective against Postoperative Cognitive Decline: CRP 1059G/C and SELP 1087G/A
- Model C-statistic = 0.7, p<0.0001
- Absolute risk reduction in Postoperative Cognitive Decline:
- 20.6% for CRP 1059C carriers
- 15.2% for SELP 1087A carriers
A Genetic Basis for Cognitive Decline After Cardiac Surgery: Intermediate Phenotypes
Mathew JP et al., JACC 2006 submitted
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