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PEGASUS Research Projects
Postoperative Sepsis
The PEGASUS team tested for an association between apolipoprotein E (APOE) genotypes and severe sepsis in surgical patients.
Blood samples, demographic data, baseline clinical data and APACHE II scores were collected from 343 patients after undergoing a major elective noncardiac surgery.
APOE genotyping was conducted and it was found that 34 (9.9%) of the patients developed severe sepsis.
Of those patients, carriers of the APOЄ3 allele had a lower incidence of severe sepsis and spent fewer days in the ICU.
Moretti et al, Crit Care Med 2005
APOE Genotype
|
Є2/Є2 |
Є2/Є3 |
Є2/Є4 |
Є3/Є3 |
Є3/Є4 |
Є4/Є4 |
Severe sepsis
(n=34) |
1 (2.9) |
5 (14.7) |
3 (8.8) |
18 (52.9) |
6 (17.6) |
1 (2.9) |
Without severe sepsis
(n=309) |
0 (0) |
42 (13.6) |
5 (1.6) |
180 (58.3) |
76 (24.6) |
6 (1.9) |
Moretti et al, Crit Care Med 2005
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