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Department of Anesthesiology
Duke University Medical Center
Box 3094
Durham, NC 27710

Office of Medical Education
Duke University Medical Center
Box 3005
Durham, NC 27710

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Recent Grant Awards

[2006] [2007] [2008]

The following departmental faculty were awarded competitive and non-competitive research grants during calendar year 2008.

Dr. Andrew Shaw of the Division of Cardiothoracic and Critical Care Medicine received a 5-year consortium award ($314,206) through the Medical University of South Carolina for a NIH Proposal (R01 DK080234) entitled “Prognostic Markers in Postoperative Acute Kidney Injury”. This study is a joint collaboration between the Medical University of South Carolina, George Washington University, the University of Texas-MD Anderson, and Duke University. In this study, the investigators will attempt to differentiate between prerenal azotemia and intrinsic renal diseases of glomerular, tubular, interstitial or vascular etiology and contrast nephropathy. We will perform additional discovery studies to identify new candidate markers to predict the cause of renal failure.

Dr. Huaxin Sheng of the Division of Basic Sciences and member of the Multidisciplinary Neuroprotection Laboratory received a 2-year $375,375 award from the National Institute of Neurological Disorders and Stroke (NINDS/NIH – R21 NS058321) to conduct a study entitled “Ethyl Nitrite and Subarachnoid Hemorrhage”. The significance of the study is to prove that selective local arterial dilation can be achieved by increasing S-nitrosyl-hemoglobin (SNO-Hb) through inhalation of ethyl nitrite and that Nitric Oxide can modulate development of Subarachnoid Hemorrhage induced cerebral vasospasm. This proposal will translate biochemical properties of SNO-Hb into new therapy and determine if increased SNO-Hb, caused by the novel s-nitrosylating agent, ethyl nitrite, improves tissue perfusion and outcomes.

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