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Department of Anesthesiology
Duke University Medical Center
Box 3094
Durham, NC 27710

Office of Medical Education
Duke University Medical Center
Box 3005
Durham, NC 27710

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Cardiopulmonary Bypass Research Laboratory
(Division of the Multidisciplinary Neuroprotection Laboratories)

The cardiopulmonary research laboratory is an active basic science laboratory established to explore the mechanisms of cerebral injury following cardiac surgery utilizing a rodent model of cardiopulmonary bypass (CPB). Ongoing research includes the investigation of several neuroprotective pharmacologic strategies, several of which have entered clinical trials. Due to the versatility of the models established, we are also actively pursing investigations into the myocardial, renal, inflammatory, and hematologic abnormalities associated with CPB.

Representative publications:

1. Grocott HP, Sato Y, Homi HM, Smith BE. The influence of xenon, nitrous oxide, and nitrogen on gas bubble expansion during cardiopulmonary bypass. Eur J Anaesth 2005; 22:1-6.
2. Homi HM, Yang H, Pearlstein RD, Grocott HP. Hemodilution during cardiopulmonary bypass increases cerebral infarct volume following middle cerebral artery occlusion in rats. Anesth Analg. 2004;99:974-981.
3. Mackensen GB, Sato Y, Nellgård B, Pineda J, Newman MF, Warner DS, Grocott HP. Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2001;95:1485-1491.
4. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2003;98:690-698.
5. Sato Y, Laskowitz DT, Bennett ER, Newman MF, Warner DS, Grocott HP. Differential cerebral gene expression during cardiopulmonary bypass in the rat: Evidence of apoptosis? Anesth Analg. 2002;94:1389-1394.

Hilary P. Grocott, MD
Associate Professor in Anesthesiology
Co-Director, Cardiopulmonary Bypass Research Laboratory
Office: (919) 681-5024
E-mail: groco001@mc.duke.edu

G. Burkhard Mackensen, MD
Associate Professor in Anesthesiology
Co-Director, Cardiopulmonary Bypass Research Laboratory
Office: (919) 684-6025
E-mail: macke009@mc.duke.edu

Laboratory staff members:

Betty E. Smith
Ma Qing, MD
Kenji Yoshitani, MD
Christopher Sulzer, MD